https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55196 Wed 24 Apr 2024 13:06:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37115 R² = .0140; P = .0082; β = .1075), but not vitamin D₂ levels. It also correlated positively with female adult height (R² = .170; P = .0103; β = .1291) and negatively with the occurrence of female osteoporosis (P = .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P = .0009). Conclusions: Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.]]> Wed 19 Aug 2020 11:35:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28251 Wed 11 Apr 2018 14:22:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24536 Wed 11 Apr 2018 09:53:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33337 Wed 06 Apr 2022 14:02:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54368 Tue 20 Feb 2024 19:58:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39975 Tue 04 Oct 2022 15:09:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55516 4 weeks) and intermittent users (n = 111, VLCD user <4 weeks and/or <4 days/week). Self-reported data on demographics, VLCD program use, support, eating behavior, weight-related QOL, mental health, physical health, self-efficacy, and physical activity. Descriptive and inferential statistics were performed in R. Results: Compared to regular users, intermittent users reported lower percentage weight loss (15.1% ± SD 9.8 vs. 9.9% ± SD 6.8, relative to starting weight), fewer reported their VLCD program as very successful (44% vs. 35%), higher depressive symptom scores (8.7 ± SD 2.8 vs. 6.7 ± SD 5.1), and lower general self-efficacy (23.9 ± SD 4.7 vs. 29.4 ± SD 5.7), nutrition self-efficacy (11.9 ± SD 2.0 vs. 14.5 ± SD 3.1) and weight-related QOL scores (60.9 ± SD 22.2 vs. 65.0 ± SD 11.8; p < 0.001 for all). In regular users, older age and longer program duration were associated with greater total weight loss, support, and program success (p < 0.001 for all). In intermittent users, program success was greater when dietitian support was used (odds ratio [OR] 6.50) and for those with higher BMIs (OR 1.08, p < 0.001 for all). In both groups, more frequent support was associated with better weight-related QOL (p < 0.001). Conclusion: This study provides real-world evidence that regular VLCD users had greater success and weight loss than intermittent program users. These findings may be used to tailor and improve the delivery of VLCD programs in Australia and other countries with retail access to VLCDs.]]> Tue 04 Jun 2024 21:00:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55129 Thu 11 Apr 2024 11:14:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28070 Sat 24 Mar 2018 10:21:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50607 Mon 31 Jul 2023 12:43:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37803 MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases. Results: A significant association between variant frequency and Fitzpatrick phototype was observed for 16 of 17 examined variants (P<.0029 Bonferroni corrected significance threshold in all cases). Conclusions: These findings demonstrate novel relationships between skin color and folate-related genes, with trends suggesting folate genotypes are selected to maintain homeostasis in the folate system under differing UVR conditions.]]> Mon 26 Apr 2021 11:48:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37802 n = 619). Red blood cell folate, 25-hydroxyvitamin D (25(OH)D), and plasma Hcy levels were determined, and genotyping for 21 folate and vitamin D-related variants was performed. Erythemal dose rate accumulated over six-weeks (6W-EDR) and four-months (4M-EDR) prior to clinics were calculated as a measure of environmental UVR. Multivariate analyses found interactions between 6W-EDR and 25(OH)D levels (p_interaction = 0.002), and 4M-EDR and MTHFD1-rs2236225 (p_interaction = 0.006) in predicting Hcy levels. The association between 6W-EDR and Hcy levels was found only in subjects within lower 25(OH)D quartiles (<33.26 ng/mL), with the association between 4M-EDR and Hcy occurring only in subjects carrying the MTHFD1-rs2236225 variant. 4M-EDR, 6W-EDR, and MTHFD1-rs2236225 were also independent predictors of Hcy. Findings highlight nutrient-environment and gene-environment interactions that could influence the risk of Hcy-related outcomes.]]> Mon 26 Apr 2021 11:34:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37801 MC1R-rs1805007, IRF4-rs12203592 and HERC2- rs12913832) on folate (red blood cell (RBC) and serum) and homocysteine levels were examined in an elderly Australian cohort (n = 599). Genotypes were assessed by RT/RFLP-PCR, and UVR exposures were assessed as the accumulated erythemal dose rate accumulated over 4 months (4M- EDR). Multivariate analysis found significant negative associations between 4M-EDR and RBC folate (p, < 0.001, ß = -0.19), serum folate (p = 0.045, ß = -0.08) and homocysteine levels (p < 0.001, ß = -0.28). Significant associations between MC1R-rs1805007 and serum folate levels (p = 0.020), and IRF4-rs12203592 and homocysteine levels (p = 0.026) occurred but did not remain significant following corrections with confounders. No interactions between 4M-EDR and pigmentation variants in predicting folate/homocysteine levels were found. UVR levels and skin pigmentation-related variants are potential determinants of folate and homocysteine status, although, associations are mixed and complex, with further studies warranted.]]> Mon 26 Apr 2021 11:13:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37800 (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP27A1, CYP24A1, VDR, RXRα and RXRγ) was collated from 60 sample sets (2633 subjects) with European, East Asian and Sub-Saharan African origin via the NCBI 1000 Genomes Browser and ALFRED (Allele Frequency Database), with the aim to examine for patterns in the distribution of vitamin D-associated variants across these geographic areas. Results: The frequency of all examined genetic variants differed between populations of European, East Asian and Sub-Saharan African ancestry. Changes in the distribution of variants in CYP2R1, CYP11A1, CYP24A1, RXRα and RXRγ genes between these populations are novel findings which have not been previously reported. The distribution of several variants reflected changes in the UVB environment of the population's ancestry. However, multiple variants displayed population-specific patterns in frequency that appears not to relate to UVB changes. Conclusions: The reported population differences in vitamin D-related variants provides insight into the extent by which activity of the vitamin D system can differ between cohorts due to genetic variance, with potential consequences for future dietary recommendations and disease outcomes.]]> Mon 26 Apr 2021 10:45:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29934 MTHFR-C677T, MTHFR-A1298C, cSHMT-C1420T TYMS 28bp 2R>3R, TYMS 3'UTR ins/del and DHFR 19bp deletion. Data extracted were analysed by the latitude of the study locations, as a surrogate measure of population UV exposure. Results: Frequency of the MTHFR-C677T and MTHFR-A1298C polymorphisms was positively associated with latitude, while a negative association was observed between latitude and frequency of the cSHMT-C1420T and TYMS 28bp 2R>3R variants. Conclusions: These findings provide novel evidence suggestive of folate genotypes being selected to maintain homeostasis between folate-dependent de novo thymidylate synthesis and methylation pathways in environments of differing UV levels. To the authors' knowledge, this is the first study to report significant associations between latitude and the occurrence of MTHFR-A1298C, TYMS 28bp 2R>3R and cSHMT-C1420T polymorphisms. On-going studies are required to further explore the biological significance of these findings.]]> Mon 26 Apr 2021 09:49:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32812 Mon 23 Sep 2019 10:19:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55685 Mon 17 Jun 2024 15:40:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33435 Fri 30 Aug 2019 12:35:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42277  3R-TS. RCF was measured by chemiluminescent immunoassay and vitamin D2 and D3 by HPLC. Results: RCF and photosynthesized vitamin D3, but not RCF and dietary vitamin D2, exhibit a significant reciprocal association in spring and summer. Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Effects are seasonal, and do not occur over the whole year. Conclusions: Findings are consistent with what might be required for the “folate-vitamin D-UV hypothesis of skin pigmentation” model. It suggests genetic influence in provision of one-carbon units by 5,10-methylene-H4folate, may be an important factor in what appears to be a clear seasonal relationship between vitamin D3 and folate status.]]> Fri 11 Aug 2023 09:43:44 AEST ]]>